Fenben Lab - Fenbendazole Powder
Pharmacology and Mechanism of Action Benzimidazole antiparasitic drug. Like other benzimidazoles, fenbendazole produces a degeneration of the parasite microtubule and irreversibly blocks glucose uptake in parasites.
Inhibition of glucose uptake causes depletion of energy stores in the parasite, eventually resulting in death. However, there is no effect on glucose metabolism in mammals. Indications and Clinical Uses Fenbendazole is effective for treatment of numerous helminth intestinal parasites including Toxacara, Toxascaris, Ancylostoma, and Trichuris. it is effective for most intestinal helminth parasites and also against nematodes.
it also has been used for pulmonary helminths (lungworms), but longer duration of treatment is needed. Fenbendazole has been effective for treatment of Giardia, but higher doses are needed and there may be failure rates as high as 50%. It is effective in cats for treatment of lungworms, flukes, and a variety of helminth parasites.
Fenbendazole fen-ben’dah-zole Trade and other names: Panacur and Safe-Guard Functional classification: Antiparasitic
Precautionary Information Adverse Reactions and Side Effects Fenbendazole has a good safety margin, but vomiting and diarrhea have been reported. When evaluated at doses of three and five times the recommended dose at three times the recommended duration, fenbendazole was well tolerated and no adverse effects were reported in the target species. It has been safe to use during pregnancy. There have been rare reports of pancytopenia associated with fenbendazole administration. Contraindications and Precautions No known contraindications. It may be used in all ages of animals. Drug Interactions There are no known drug interactions.
Pharmacological (biological) properties and effects of fenbendazole
The anti-gelmintic agent of the benzimidazole group. Fenbendazole (5-phenyl-tio-2-benzimidizole carbamat) has a wide range of nematodic and cesodocide, active against adult forms, larvae and eggs of necatode of the gastrointestinal tract and lungs, as well as cystods parasitizing.
The mechanism of action of fenbendazole is to destroy the microchannels in the cells of the intestine helminths and disrupt the energy processes, which leads to the death of parasites.
With oral administration, fenbendazole is easily absorbed into the intestines and distributed in the organs and tissues of the animal; secretes from the body in the constant form and in the form of metabolites, mainly with bile and partly with urine.
Chemical substance is packaged on 1, 10, 100, 500, 1000 g in plastic bags, vials and cans of glass. Plastic bags of 10 and 25 kg.
Storage: In a dry place at temperatures ranging from 0 degrees Celsius to 25 degrees Celsius.
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